February 26, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No:  Pending

August 1, 2019

A. Valance Washington

Appl. No.: 16/242,995
Docket: UPR-14230

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627


March 30, 2015
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.

West RJH, Lu Y, Marie B, Gao F-B, Sweeney ST
J. Cell Biol. 2015; 208 (7): 931–947. DOI: 10.1083/jcb.201404066

March 1, 2015
Tamoxifen and Src kinase inhibitors as neuroprotective/neuroregenerative drugs after spinal cord injury.

Salgado IK, Torrado AI, Santiago JM, Miranda JD
Neural Regen. Res. 2015; 10 (3): 385–390. DOI: 10.4103/1673-5374.153685

January 1, 2015
The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component.

Delgado Y, Morales-Cruz M, Figueroa CM, Hernández-Román J, Hernández G, Griebenow K
FEBS Open Bio. 2015; 5 (1): 397–404. DOI: 10.1016/j.fob.2015.04.010

December 15, 2014
Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue.

Rosas OR, Torrado AI, Santiago JM, Rodriguez AE, Salgado IK, Miranda JD
Neural Regen. Res. 2014; 9 (24): 2164–2173. DOI: 10.4103/1673-5374.147949

October 17, 2014
Large conductance voltage- and Ca2+-gated potassium (BK) channel β4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases.

Velázquez-Marrero C, Seale GE, Treistman SN, Martin GE
J. Biol. Chem. 2014; 289 (42): 29261–29272. DOI: 10.1074/jbc.M114.604306

September 25, 2014
Lipids modulate the increase of BK channel calcium sensitivity by the β1 subunit.

Yuan C, Velázquez-Marrero C, Bernardo A, Treistman SN
PloS One. 2014; 9 (9): e107917. DOI: 10.1371/journal.pone.0107917

September 2, 2014
Activation of caspase-dependent apoptosis by intracellular delivery of cytochrome c-based nanoparticles.

Morales-Cruz M, Figueroa CM, González-Robles T, Delgado Y, Molina A, Méndez J, Morales M, Griebenow K
J. Nanobiotechnology. 2014; 12 33. DOI: 10.1186/s12951-014-0033-9

August 27, 2014
Engrailed Alters the Specificity of Synaptic Connections of Drosophila Auditory Neurons with the Giant Fiber.

Pézier A, Jezzini SH, Marie B, Blagburn JM
J. Neurosci. Off. J. Soc. Neurosci. 2014; 34 (35): 11691–11704. DOI: 10.1523/JNEUROSCI.1939-14.2014

August 6, 2014
Chemical glycosylation of cytochrome c improves physical and chemical protein stability.

Delgado Y, Morales-Cruz M, Hernández-Román J, Martínez Y, Griebenow K
BMC Biochem. 2014; 15 16. DOI: 10.1186/1471-2091-15-16

August 1, 2014
Localization of tyrosine hydroxylase-like immunoreactivity in the nervous systems of Biomphalaria glabrata and Biomphalaria alexandrina, intermediate hosts for schistosomiasis.

Vallejo D, Habib MR, Delgado N, Vaasjo LO, Croll RP, Miller MW
J. Comp. Neurol. 2014; 522 (11): 2532–2552. DOI: 10.1002/cne.23548

May 2, 2014
Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha.

Mosquera L, Colón JM, Santiago JM, Torrado AI, Meléndez M, Segarra AC, Rodríguez-Orengo JF, Miranda JD
Brain Res. 2014; 1561 11–22. DOI: 10.1016/j.brainres.2014.03.002

April 17, 2014
Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review.

Rivera-Oliver M, Díaz-Ríos M
Life Sci. 2014; 101 (1–2): 1–9. DOI: 10.1016/j.lfs.2014.01.083

April 1, 2014
Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria.

Hernández JS, Barreto-Torres G, Kuznetsov AV, Khuchua Z, Javadov S
J. Cell. Mol. Med. 2014; 18 (4): 709–720. DOI: 10.1111/jcmm.12220

March 5, 2014
μ-Opioid Inhibition of Ca2+ Currents and Secretion in Isolated Terminals of the Neurohypophysis Occurs via Ryanodine-Sensitive Ca2+ Stores.

Velázquez-Marrero C, Ortiz-Miranda S, Marrero HG, Custer EE, Treistman SN, Lemos JR
J. Neurosci. Off. J. Soc. Neurosci. 2014; 34 (10): 3733–3742. DOI: 10.1523/JNEUROSCI.2505-13.2014

January 6, 2014
Delivery of Chemically Glycosylated Cytochrome c Immobilized in Mesoporous Silica Nanoparticles Induces Apoptosis in HeLa Cancer Cells.

Méndez J, Morales Cruz M, Delgado Y, Figueroa CM, Orellano EA, Morales M, Monteagudo A, Griebenow K
Mol. Pharm. 2014; 11 (1): 102–111. DOI: 10.1021/mp400400j