PATENTS

 USPTO
Pat Num
TitleInventorsDate
110676518A4B2 nicotinic acetylcholine receptors with
reduced or increased nicotine sensitivity and transgenic mouse model for the same.
Caballero-Rivera; Daniel, Biaggi-
Labiosa; Nilza M, Aviles-Pagan; Emir, Lasalde-Dominicci; José A.
April 2016
29,650,627Site-directed RNA editingRosenthal; Joshua J. C., Montiel-Gonzalez; Maria FernandaMay 2017
310,106,572Supramolecular hacky sacks (SHS), method of synthesis and applications thereofRivera; Jose M, Negron; Luis MOct 2018
410,155,221High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition.Lasalde-Dominicci; Jose A., Quesada-Gonzalez;
Orestes, Rodriguez-Cordero; Josue, Baez-Pagan; Carlos
Dec 2018
510,358,475High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable compositionJose A. Lasalde-Dominicci, Orestes Quesada-Gonzalez, Josue Rodriguez-Cordero, Carlos Baez- PaganJuly 2019
610,597,462Anti-TLT-1 antibody and uses thereofWashington Anthony VMarch 2020
715/996,946High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable compositionJose A. Lasalde-DominicciApril 2022
June 9, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No: 10,676,518

March 24, 2020
ANTI-TLT-1 ANTIBODY AND USES THEREOF

Valance-Washington A, Ferrer-Acosta Y, Morales J, Reyes-Baez F

U.S. Patent No: 10,597,462

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

December 18, 2018
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; José A., Quesada-González; Orestes, Rodríguez-Cordero, Josué, Báez-Pagan; Carlos

U.S. Patent No: 10,155,221

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627

PUBLICATIONS

May 26, 2021
FMRF-NH 2 -Related Neuropeptides in Biomphalaria spp., Intermediate Hosts for Schistosomiasis: Precursor Organization and Immunohistochemical Localization

Solymar Rolón-Martínez, Mohamed R Habib, Tamer A Mansour, Manuel Díaz-Ríos, Joshua J C Rosenthal, Xiao-Nong Zhou, Roger P Croll, Mark W Miller.
J Comp Neurol. 2021 May 26. doi: 10.1002/cne.25195.

April 20, 2021
Cnr2 is Important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors

Colón-Cruz L, Rodriguez-Morales R, Santana-Cruz A, Cantres-Velez J, Torrado-Tapias A, Lin S.J, Yudowski G, Kensler R, Marie B, Burgess S.M, Renaud O, Varshney G.K, Behra M.
Front. Mol. Neurosci., 20 April 2021

March 31, 2021
Disruption of the cholinergic anti-inflammatory response by R5-tropic HIV-1 protein gp120 JRFL

Cotto Ríos S, Colón Sáez J.O, Quesada O, Quiroz Figueroa K, Lasalde Dominicci J. A,
J Biol Chem. 2021 Mar 31;100618. doi 10.1016/j.jbc.2021.100618. Online ahead of print.

February 22, 2021
Rearing methods and life cycle characteristics of Chironomus sp. Florida (Chironomidae: Diptera): A rapid-developing species for laboratory studies

Reyes-Maldonado R, Marie B, Ramírez A,
PLoS One. 2021 Feb 22;16(2):e0247382. doi: 10.1371/journal.pone.0247382. eCollection 2021.

January 27, 2021
A reversed phase HPLC method for the quantification of HIV gp145 glycoprotein levels from cell culture supernatants

González-Feliciano JA, Capó-Vélez CM, Akamine PY, Delgado-Vélez M, Almodóvar R, Pino I, Morell G, Eichinger D, Rivera JH, Lasalde-Dominicci JA, Baerga-Ortiz A,
J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 27;1167:122562. doi:10.1016/j.jchromb.2021.122562.

December 25, 2020
Identification and localization of a gonadotropin‐releasing hormone‐related neuropeptide in Biomphalaria, an intermediate host for schistosomiasis

Rosa‐Casillas M, Méndez de Jesús P, Vicente-Rodríguez L.C, Habib M.R, Croll R.P, Miller M.W,
J Comp Neurol. 2021 Jun;529(9):2347-2361. doi: 10.1002/cne.25099. Epub 2021 Jan 27.

August 24, 2020
Biophysical characterization dataset of native nicotinic acetylcholine receptor in lipid-like detergent complexes

Maldonado-Hernández R, Quesada O, Lasalde-Dominicci JA.
Data Brief. 2020 Aug 27;32:106230. doi: 10.1016/j.dib.2020.106230. eCollection 2020 Oct.

August 8, 2020
Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis

Miller M.W
Biol Bull. 2020 Dec;239(3):189-208. doi: 10.1086/711293. Epub 2020 Nov 20.

August 4, 2020
Sequential purification and characterization of Torpedo californica nAChR-DC supplemented with CHS for high-resolution crystallization studies

Maldonado-Hernández R, Quesada O, Colón-Sáez JO, Lasalde-Dominicci JA.
Anal Biochem. 2020 Dec 1;610:113887. doi: 10.1016/j.ab.2020.113887. Epub 2020 Aug 4.

June 19, 2020
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and antigenicity

González-Feliciano JA, Akamine P, Capó-Vélez CM, Delgado-Vélez M, Dussupt V, Krebs SJ, Wojna V, Polonis VR, Baerga-Ortiz A, Lasalde-Dominicci JA.
PLoS One. 2020 Jun 19;15(6):e0231679. doi: 10.1371/journal.pone.0231679. eCollection 2020.

April 1, 2019
GABA as a Neurotransmitter in Gastropod Molluscs

Miller MW
Biol Bull. 2019;236(2):144-156. DOI: 10.1086/701377.

March 26, 2019
An Immunohistochemical Analysis of Peptidergic Neurons Apparently Associated with Reproduction and Growth in Biomphalaria alexandrina

Acker MJ, Habib MR, Beach GA, Doyle JM, Miller MW, Croll RP
Gen Comp Endocrinol. 2019. pii: S0016-6480(18)30573-2. DOI: 10.1016/j.ygcen.2019.03.017

February 1, 2019
Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron

Rivera-Oliver M, Moreno E, Álvarez-Bagnarol Y, Ayala-Santiago C, Cruz-Reyes N, Molina-Castro GC, Clemens S, Canela EI, Ferré S, Casadó V, Díaz-Ríos M
Mol Neurobiol. 2019;56(2):797-811. DOI: 10.1007/s12035-018-1120-y

January 1, 2019
Amphetamine enantiomers inhibit homomeric α7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans

Garton DR, Ross SG, Maldonado-Hernández R, Quick M, Lasalde-Dominicci JA, Lizardi-Ortiz JE
Neuropharmacology. 2019;144:172-183. DOI: 10.1016/j.neuropharm.2018.10.032

December 26, 2018
A role for dopamine in the peripheral sensory processing of a gastropod mollusc

Brown JW, Schaub BM, Klusas BL, Tran AX, Duman AJ, Haney SJ, Boris AC, Flanagan MP, Delgado
N, Torres G, Rolón-Martínez S, Vaasjo LO, Miller MW, Gillette R
PLoS One. 2018;13(12):e0208891. DOI: 10.1371/journal.pone.0208891

PRESENTATIONS

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Presentations Sponsored by COBRE