PATENTS

USPTO
Pat Num		TitleInventorsDate
110,155,221 High-throughput
crystallographic screening
device and method for
crystalizing membrane
proteins using a sub
physiological resting
membrane potential across
a lipid matrix of variable
composition.		Lasalde-Dominicci;
Jose A., QuesadaGonzalez; Orestes,
Rodriguez-Cordero;
Josue, Baez-Pagan;
Carlos		December
2018
210,106,572Supramolecular hacky
sacks (SHS), method of
synthesis and applications
thereof		Rivera; Jose M,
Negron; Luis M		October
2018
39,650,627Site-directed RNA editingRosenthal; Joshua J. C.,
Montiel-Gonzalez; Maria
Fernanda		May 2017
410,676,518A4B2 nicotinic
acetylcholine receptors
with reduced or increased
nicotine sensitivity and
transgenic mouse model
for the same.		Caballero-Rivera; Daniel,
Biaggi-Labiosa; Nilza M,
Aviles-Pagan; Emir,
Lasalde-Dominicci; José
A.		June 2020
510,358,475High-throughput
crystallographic screening
device and method for
crystalizing membrane
proteins using a sub
physiological resting
membrane potential across
a lipid matrix of variable
composition		Jose A. LasaldeDominicci, Orestes
Quesada-Gonzalez, Josue
Rodriguez-Cordero,
Carlos Baez-Pagan		July 2019
610,597,462Anti-TLT-1 antibody and
uses thereof		Washigton Anthony VMarch 2020
711,440,001High-throughput
crystallographic screening
device and method for
crystalizing membrane
proteins using a sub
September 2022
8physiological resting
membrane potential across
a lipid matrix of variable
composition
April 1, 2022
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Jose A. Lasalde-Dominicci

U.S. Patent No: Pending

June 9, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No: 10,676,518

March 24, 2020
ANTI-TLT-1 ANTIBODY AND USES THEREOF

Valance-Washington A, Ferrer-Acosta Y, Morales J, Reyes-Baez F

U.S. Patent No: 10,597,462

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

December 18, 2018
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; José A., Quesada-González; Orestes, Rodríguez-Cordero, Josué, Báez-Pagan; Carlos

U.S. Patent No: 10,155,221

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627

 

PUBLICATIONS

Publications up to April 2025  ” View pdf ” ⇒

September 25, 2014
Lipids modulate the increase of BK channel calcium sensitivity by the β1 subunit.

Yuan C, Velázquez-Marrero C, Bernardo A, Treistman SN
PloS One. 2014; 9 (9): e107917. DOI: 10.1371/journal.pone.0107917

September 2, 2014
Activation of caspase-dependent apoptosis by intracellular delivery of cytochrome c-based nanoparticles.

Morales-Cruz M, Figueroa CM, González-Robles T, Delgado Y, Molina A, Méndez J, Morales M, Griebenow K
J. Nanobiotechnology. 2014; 12 33. DOI: 10.1186/s12951-014-0033-9

August 27, 2014
Engrailed Alters the Specificity of Synaptic Connections of Drosophila Auditory Neurons with the Giant Fiber.

Pézier A, Jezzini SH, Marie B, Blagburn JM
J. Neurosci. Off. J. Soc. Neurosci. 2014; 34 (35): 11691–11704. DOI: 10.1523/JNEUROSCI.1939-14.2014

August 6, 2014
Chemical glycosylation of cytochrome c improves physical and chemical protein stability.

Delgado Y, Morales-Cruz M, Hernández-Román J, Martínez Y, Griebenow K
BMC Biochem. 2014; 15 16. DOI: 10.1186/1471-2091-15-16

August 1, 2014
Localization of tyrosine hydroxylase-like immunoreactivity in the nervous systems of Biomphalaria glabrata and Biomphalaria alexandrina, intermediate hosts for schistosomiasis.

Vallejo D, Habib MR, Delgado N, Vaasjo LO, Croll RP, Miller MW
J. Comp. Neurol. 2014; 522 (11): 2532–2552. DOI: 10.1002/cne.23548

May 2, 2014
Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha.

Mosquera L, Colón JM, Santiago JM, Torrado AI, Meléndez M, Segarra AC, Rodríguez-Orengo JF, Miranda JD
Brain Res. 2014; 1561 11–22. DOI: 10.1016/j.brainres.2014.03.002

April 17, 2014
Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review.

Rivera-Oliver M, Díaz-Ríos M
Life Sci. 2014; 101 (1–2): 1–9. DOI: 10.1016/j.lfs.2014.01.083

April 1, 2014
Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria.

Hernández JS, Barreto-Torres G, Kuznetsov AV, Khuchua Z, Javadov S
J. Cell. Mol. Med. 2014; 18 (4): 709–720. DOI: 10.1111/jcmm.12220

March 5, 2014
μ-Opioid Inhibition of Ca2+ Currents and Secretion in Isolated Terminals of the Neurohypophysis Occurs via Ryanodine-Sensitive Ca2+ Stores.

Velázquez-Marrero C, Ortiz-Miranda S, Marrero HG, Custer EE, Treistman SN, Lemos JR
J. Neurosci. Off. J. Soc. Neurosci. 2014; 34 (10): 3733–3742. DOI: 10.1523/JNEUROSCI.2505-13.2014

January 6, 2014
Delivery of Chemically Glycosylated Cytochrome c Immobilized in Mesoporous Silica Nanoparticles Induces Apoptosis in HeLa Cancer Cells.

Méndez J, Morales Cruz M, Delgado Y, Figueroa CM, Orellano EA, Morales M, Monteagudo A, Griebenow K
Mol. Pharm. 2014; 11 (1): 102–111. DOI: 10.1021/mp400400j

January 1, 2014
Ciliary neurotrophic factor and fibroblast growth factor increase the speed and number of regenerating axons after optic nerve injury in adult Rana pipiens.

Vega-Meléndez GS, Blagburn JM, Blanco RE
J. Neurosci. Res. 2014; 92 (1): 13–23. DOI: 10.1002/jnr.23303

December 1, 2013
Differential expression and localization of saposin-like protein 2 of Fasciola hepatica.

Cabán-Hernández K, Espino AM
Acta Trop. 2013; 128 (3): 591–597. DOI: 10.1016/j.actatropica.2013.08.012

December 1, 2013
Removing sensory input disrupts spinal locomotor activity in the early postnatal period.

Acevedo JM, Díaz-Ríos M
J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 2013; 199 (12): 1105–1116. DOI: 10.1007/s00359-013-0853-3

November 1, 2013
Luminescent graphene quantum dots fabricated by pulsed laser synthesis.

Habiba K, Makarov VI, Avalos J, Guinel MJF, Weiner BR, Morell G
Carbon. 2013; 64 341–350. DOI: 10.1016/j.carbon.2013.07.084

August 5, 2013
Auditory responses of engrailed and invected-expressing Johnston’s Organ neurons in Drosophila melanogaster.

Pézier A, Blagburn JM
PloS One. 2013; 8 (8): e71419. DOI: 10.1371

PRESENTATIONS

Some of the presentations sponsored by COBRE and NIEF cores could be observed in this file:

Presentations Sponsored by COBRE