PATENTS

June 9, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No: 10,676,518

March 24, 2020
ANTI-TLT-1 ANTIBODY AND USES THEREOF

Valance-Washington A, Ferrer-Acosta Y, Morales J, Reyes-Baez F

U.S. Patent No: 10,597,462

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627

PUBLICATIONS

November 1, 2016
The Multiple Waves of Cannabinoid 1 Receptor Signaling

Nogueras-Ortiz C, Yudowski GA
Mol. Pharmacol. 2016; 90 (5): 620–626. DOI: 10.1124/mol.116.104539

October 12, 2016
Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling

Velázquez-Marrero C, Burgos A, García JO, Palacio S, Marrero HG, Bernardo A, Pérez-Laspiur J,
Rivera-Oliver M, Seale G, Treistman SN
J. Neurosci. Off. J. Soc. Neurosci. 2016; 36 (41): 10625–10639. DOI: 10.1523/JNEUROSCI.0491-
16.2016

October 1, 2016
Cystatin B and HIV Regulate the STAT-1 Signaling Circuit in HIV-Infected and INF-β-Treated Human Macrophages

Rivera LE, Kraiselburd E, Meléndez LM
J. Neurovirol. 2016; 22 (5): 666–673. DOI: 10.1007/s13365-016-0443-6

September 19, 2016
Uncovering the Lipidic Basis for the Preparation of Functional Nicotinic Acetylcholine Receptor Detergent Complexes for Structural Studies

Quesada O, González-Freire C, Ferrer MC, Colón-Sáez JO, Fernández-García E, Mercado J, Dávila A, Morales R, Lasalde-Dominicci JA
Sci. Rep. 2016; 6 32766. DOI: 10.1038/srep32766

September 15, 2016
Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats

Colón JM, Torrado AI, Cajigas Á, Santiago JM, Salgado IK, Arroyo Y, Miranda JD
J. Neurotrauma. 2016; 33 (18): 1696–1708. DOI: 10.1089/neu.2015.4111

September 9, 2016
Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury

Duprey-Díaz MV, Blagburn JM, Blanco RE
PloS One. 2016; 11 (9): e0162626. DOI: 10.1371/journal.pone.0162626

August 1, 2016
Heterogeneous Inhibition in Macroscopic Current Responses of Four Nicotinic Acetylcholine Receptor Subtypes by Cholesterol Enrichment.

Báez-Pagán CA, Del Hoyo-Rivera N, Quesada O, Otero-Cruz JD, Lasalde-Dominicci JA
J. Membr. Biol. 2016; 249 (4): 539–549. DOI: 10.1007/s00232-016-9896-z

August 1, 2016
Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury

Figueroa JD, Serrano-Illan M, Licero J, Cordero K, Miranda JD, De Leon M
J. Neurotrauma. 2016; 33 (15): 1436–1449. DOI: 10.1089/neu.2015.4186

August 1, 2016
Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery.

Colón JM, Miranda JD
Neural Regen. Res. 2016; 11 (8): 1208–1211. DOI: 10.4103/1673-5374.189164

August 1, 2016
Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome C Nanoparticles in Tumor Cells

Morales-Cruz M, Cruz-Montañez A, Figueroa CM, González-Robles T, Davila J, Inyushin M, Loza-Rosas SA, Molina AM, Muñoz-Perez L, Kucheryavykh LY, Tinoco AD, Griebenow K
Mol. Pharm. 2016; 13 (8): 2844–2854. DOI: 10.1021/acs.molpharmaceut.6b00461

June 3, 2016
Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells

Martinez NA, Ayala AM, Martinez M, Martinez-Rivera FJ, Miranda JD, Silva WI
J. Biol. Chem. 2016; 291 (23): 12208–12222. DOI: 10.1074/jbc.M116.730226

June 1, 2016
Redox-Sensitive Cross-Linking Enhances Albumin Nanoparticle Function as Delivery System for Photodynamic Cancer Therapy.

Molina AM, Morales-Cruz M, Benítez M, Berríos K, Figueroa CM, Griebenow K
J. Nanomedicine Nanotechnol. 2016; 6 (3): 1–8. DOI: 10.4172/2157-7439.1000294

June 1, 2016
Expression of CHRFAM7A and CHRNA7 in Neuronal Cells and Postmortem Brain of HIV-Infected Patients: Considerations for HIV-Associated Neurocognitive Disorder

Ramos FM, Delgado-Vélez M, Ortiz ÁL, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA
J. Neurovirol. 2016; 22 (3): 327–335. DOI: 10.1007/s13365-015-0401-8

June 1, 2016
Decreased glial and synaptic glutamate uptake in striatum of HIV-1 gp120 transgenic mice.

Melendez RI, Roman C, Capo-Velez CM, Lasalde-Dominicci JA
J. Neurovirol. 2016; 22 (3): 358–365. DOI: 10.1007/s13365-015-0403-6

June 1, 2016
Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor.

Delgado-Peraza F, Ahn KH, Nogueras-Ortiz C, Mungrue IN, Mackie K, Kendall DA, Yudowski GA
Mol. Pharmacol. 2016; 89 (6): 618–629. DOI: 10.1124/mol.115.103176