PATENTS

 USPTO
Pat Num		TitleInventorsDate
110676518A4B2 nicotinic acetylcholine receptors with
reduced or increased nicotine sensitivity and transgenic mouse model for the same.		Caballero-Rivera; Daniel, Biaggi-
Labiosa; Nilza M, Aviles-Pagan; Emir, Lasalde-Dominicci; José A.		April 2016
29,650,627Site-directed RNA editingRosenthal; Joshua J. C., Montiel-Gonzalez; Maria FernandaMay 2017
310,106,572Supramolecular hacky sacks (SHS), method of synthesis and applications thereofRivera; Jose M, Negron; Luis MOct 2018
410,155,221High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition.Lasalde-Dominicci; Jose A., Quesada-Gonzalez;
Orestes, Rodriguez-Cordero; Josue, Baez-Pagan; Carlos		Dec 2018
510,358,475High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable compositionJose A. Lasalde-Dominicci, Orestes Quesada-Gonzalez, Josue Rodriguez-Cordero, Carlos Baez- PaganJuly 2019
610,597,462Anti-TLT-1 antibody and uses thereofWashington Anthony VMarch 2020
715/996,946High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable compositionJose A. Lasalde-DominicciApril 2022
April 1, 2022
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Jose A. Lasalde-Dominicci

U.S. Patent No: Pending

June 9, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No: 10,676,518

March 24, 2020
ANTI-TLT-1 ANTIBODY AND USES THEREOF

Valance-Washington A, Ferrer-Acosta Y, Morales J, Reyes-Baez F

U.S. Patent No: 10,597,462

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

December 18, 2018
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; José A., Quesada-González; Orestes, Rodríguez-Cordero, Josué, Báez-Pagan; Carlos

U.S. Patent No: 10,155,221

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627

PUBLICATIONS

December 6, 2018
Platelet-Derived TLT-1 Is a Prognostic Indicator in ALI/ARDS and Prevents Tissue Damage in the Lungs in a Mouse Model

Morales-Ortíz J, Deal V, Reyes F, Maldonado-Martínez G, Ledesma N, Staback F, Croft C,
Pacheco A, Ortiz-Zuazaga H, Yost CC, Rowley JW, Madera B, John AS, Chen J, Lopez J, Rondina
MT, Hunter R, Gibson A, Washington AV
Blood. 2018;132(23):2495-2505. DOI: 10.1182/blood-2018-03-841593

December 1, 2018
New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and their Implications for Neuropsychiatric Disorders

Ferré S, Díaz-Ríos M, Salamone JD, Prediger RD
J Caffeine Adenosine Res. 2018;8(4):121-131. DOI: 10.1089/caff.2018.0017

October 1, 2018
Nicotinic Acetylcholine Receptors in HIV: Possible Roles during HAND and Inflammation

Capó-Vélez CM, Delgado-Vélez M, Báez-Pagán CA, Lasalde-Dominicci JA
Cell Mol Neurobiol. 2018; 38(7):1335-1348. DOI: 10.1007/s10571-018-0603-8

August 1, 2018
GABA-Like Immunoreactivity in Biomphalaria: Colocalization with Tyrosine Hydroxylase-Like Immunoreactivity in the Feeding Motor Systems of Panpulmonate Snails

Vaasjo LO, Quintana AM, Habib MR, Mendez de Jesus PA, Croll RP, Miller MW
J Comp Neurol. 2018;526(11):1790-1805. DOI: 10.1002/cne.24448

July 15, 2018
T1- and T2-Weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion

Thapa B, Diaz-Diestra D, Santiago-Medina C, Kumar N, Tu K, Beltran-Huarac J, Jadwisienczak
WM, Weiner BR, Morell G
ACS Appl Bio Mater. 2018;1(1):79-89. DOI: 10.1021/acsabm.8b00016

May 16, 2018
The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation

Delgado-Vélez M, Lasalde-Dominicci JA
Int J Mol Sci. 2018;19(5). pii: E1473. DOI: 10.3390/ijms19051473

April 12, 2018
Inducing Cell Death In Vitro in Cancer Cells by Targeted Delivery of Cytochrome C via a Transferrin Conjugate

Saxena M, Delgado Y, Sharma RK, Sharma S, Guzmán SLPL, Tinoco AD, Griebenow K
PLoS One. 2018;13(4):e0195542. DOI: 10.1371/journal.pone.0195542

April 1, 2018
The Characterization of Monoclonal Antibodies to Mouse TLT-1 Suggests That TLT-1 Plays a Role in Wound Healing

Barbara M, Morales-Ortíz J, Díaz-Díaz LM, Hernandez-Matias L, Barreto-Vázquez D, Menéndez-Pérez J,Rodríguez-Cordero JA,Villalobos-Santos JC,Santiago-Rivera E, Rivera-Dompenciel A,Lozada-Delgado EL, Kuchibhotla M, Carrasquillo-Carrión K, Roche-Lima A, and Washington AV. Monoclon Antib

Immunodiagn Immunother. 2018 Apr 1; 37(2): 78–86. DOI: 10.1089/mab.2017.0063

March 28, 2018
TLT-1-Controls Early Thrombus Formation and Stability by Facilitating AIIBB3 Outside-In Signaling in Mice

Morales-Ortíz J, Reyes F, Santiago O, Rivera L, Ledesma N, Manne B, Madera B, Rondina MT and Washington AV. Int J Adv

Res (Indore). 2018 Mar;6(3):1143-1149. DOI: 10.21474/IJAR01/7469.

January 29, 2018
The Alpha7-Nicotinic Receptor Contributes to GP120-Induced Neurotoxicity: Implications in HIV-Associated Neurocognitive Disorders

Capó-Vélez CM, Morales-Vargas B, García-González A, Grajales-Reyes JG, Delgado-Vélez M, Madera B, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA
Sci Rep. 2018;8(1):1829. doi: 10.1038/s41598-018-20271-x

January 8, 2018
Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome

Ferré S, Quiroz C, Guitart X, Rea W, Seyedian A, Moreno E, Casadó-Anguera V, Díaz-Ríos M,
Casadó V, Clemens S, Allen RP, Earley CJ, García-Borreguero D
Front Neurosci. 2018;11:722. DOI: 10.3389/fnins.2017.00722

January 1, 2018
Continuous Tamoxifen Delivery Improves Locomotor Recovery 6h After Spinal Cord Injury by Neuronal and Glial Mechanisms in Male Rats

Colón JM, González PA, Cajigas Á, Maldonado WI, Torrado AI, Santiago JM, Salgado IK, Miranda JD
Exp Neurol. 2018;299(Pt A):109-121. DOI: 10.1016/j.expneurol.2017.10.006

November 15, 2017
Retromer Stops Beta-Arrestin 1-Mediated Signaling from Internalized Cannabinoid 2 Receptors

Nogueras-Ortiz C, Roman-Vendrell C, Mateo-Semidey GE, Liao YH, Kendall DA, Yudowski GA
Mol Biol Cell. 2017;28(24):3554-3561. DOI: 10.1091/mbc.E17-03-0198

September 9, 2017
Simultaneous Activation of Parallel Sensory Pathways Promotes a Grooming Sequence in Drosophila

Hampel S, McKellar CE, Simpson JH, Seeds AM
eLife. 2017; 6DOI: 10.7554/eLife.28804

July 17, 2017
Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.

Loza-Rosas SA, Vázquez-Salgado AM, Rivero KI, Negrón LJ, Delgado Y, Benjamín-Rivera JA,
Vázquez-Maldonado AL, Parks TB, Munet-Colón C, Tinoco AD.
Inorg Chem. 2017;56(14):7788-7802. DOI: 10.1021/acs.inorgchem.7b00542.

PRESENTATIONS

Some of the presentations sponsored by COBRE and NIEF cores could be observed in this file:

Presentations Sponsored by COBRE