PATENTS

 USPTO
Pat Num		TitleInventorsDate
110676518A4B2 nicotinic acetylcholine receptors with
reduced or increased nicotine sensitivity and transgenic mouse model for the same.		Caballero-Rivera; Daniel, Biaggi-
Labiosa; Nilza M, Aviles-Pagan; Emir, Lasalde-Dominicci; José A.		April 2016
29,650,627Site-directed RNA editingRosenthal; Joshua J. C., Montiel-Gonzalez; Maria FernandaMay 2017
310,106,572Supramolecular hacky sacks (SHS), method of synthesis and applications thereofRivera; Jose M, Negron; Luis MOct 2018
410,155,221High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition.Lasalde-Dominicci; Jose A., Quesada-Gonzalez;
Orestes, Rodriguez-Cordero; Josue, Baez-Pagan; Carlos		Dec 2018
510,358,475High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable compositionJose A. Lasalde-Dominicci, Orestes Quesada-Gonzalez, Josue Rodriguez-Cordero, Carlos Baez- PaganJuly 2019
610,597,462Anti-TLT-1 antibody and uses thereofWashington Anthony VMarch 2020
715/996,946High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable compositionJose A. Lasalde-DominicciApril 2022
April 1, 2022
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Jose A. Lasalde-Dominicci

U.S. Patent No: Pending

June 9, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No: 10,676,518

March 24, 2020
ANTI-TLT-1 ANTIBODY AND USES THEREOF

Valance-Washington A, Ferrer-Acosta Y, Morales J, Reyes-Baez F

U.S. Patent No: 10,597,462

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

December 18, 2018
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; José A., Quesada-González; Orestes, Rodríguez-Cordero, Josué, Báez-Pagan; Carlos

U.S. Patent No: 10,155,221

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627

PUBLICATIONS

August 1, 2016
Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome C Nanoparticles in Tumor Cells

Morales-Cruz M, Cruz-Montañez A, Figueroa CM, González-Robles T, Davila J, Inyushin M, Loza-Rosas SA, Molina AM, Muñoz-Perez L, Kucheryavykh LY, Tinoco AD, Griebenow K
Mol. Pharm. 2016; 13 (8): 2844–2854. DOI: 10.1021/acs.molpharmaceut.6b00461

June 3, 2016
Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells

Martinez NA, Ayala AM, Martinez M, Martinez-Rivera FJ, Miranda JD, Silva WI
J. Biol. Chem. 2016; 291 (23): 12208–12222. DOI: 10.1074/jbc.M116.730226

June 1, 2016
Redox-Sensitive Cross-Linking Enhances Albumin Nanoparticle Function as Delivery System for Photodynamic Cancer Therapy.

Molina AM, Morales-Cruz M, Benítez M, Berríos K, Figueroa CM, Griebenow K
J. Nanomedicine Nanotechnol. 2016; 6 (3): 1–8. DOI: 10.4172/2157-7439.1000294

June 1, 2016
Expression of CHRFAM7A and CHRNA7 in Neuronal Cells and Postmortem Brain of HIV-Infected Patients: Considerations for HIV-Associated Neurocognitive Disorder

Ramos FM, Delgado-Vélez M, Ortiz ÁL, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA
J. Neurovirol. 2016; 22 (3): 327–335. DOI: 10.1007/s13365-015-0401-8

June 1, 2016
Decreased glial and synaptic glutamate uptake in striatum of HIV-1 gp120 transgenic mice.

Melendez RI, Roman C, Capo-Velez CM, Lasalde-Dominicci JA
J. Neurovirol. 2016; 22 (3): 358–365. DOI: 10.1007/s13365-015-0403-6

June 1, 2016
Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor.

Delgado-Peraza F, Ahn KH, Nogueras-Ortiz C, Mungrue IN, Mackie K, Kendall DA, Yudowski GA
Mol. Pharmacol. 2016; 89 (6): 618–629. DOI: 10.1124/mol.115.103176

April 4, 2016
Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster.

Pézier AP, Jezzini SH, Bacon JP, Blagburn JM
PloS One. 2016; 11 (4): e0152211. DOI: 10.1371/journal.pone.0152211

March 15, 2016
Organic Nanoflowers from a Wide Variety of Molecules Templated by a Hierarchical Supramolecular Scaffold.

Negrón LM, Díaz TL, Ortiz-Quiles EO, Dieppa-Matos D, Madera-Soto B, Rivera JM
Langmuir ACS J. Surf. Colloids. 2016; 32 (10): 2283–2290. DOI: 10.1021/acs.langmuir.5b03946

March 1, 2016
Functionality and stability data of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.

Padilla-Morales LF, Colón-Sáez JO, González-Nieves JE, Quesada-González O, Lasalde-Dominicci JA
Data Brief. 2016; 6 (Supplement C): 433–437. DOI: 10.1016/j.dib.2015.12.010

February 1, 2016
Caffeine stimulates locomotor activity in the mammalian spinal cord via an A1/D1 receptor and PKA-dependent mechanisms.

Acevedo J, Santana-Almansa A, Matos-Vergara N, Marrero-Cordero LR, Cabezas-Bou E, Díaz-Ríos M
Neuropharmacology. 2016; 101 (Supplement C): 490–505. DOI: 10.1016/j.neuropharm.2015.10.020

January 1, 2016
Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.

Padilla-Morales LF, Colón-Sáez JO, González-Nieves JE, Quesada-González O, Lasalde-Dominicci JA
Biochim. Biophys. Acta. 2016; 1858 (1): 47–56. DOI: 10.1016/j.bbamem.2015.10.002

December 11, 2015
The ∂7 nicotinic receptor is up-regulated in macrophages from HIV-seropositive women: Consequences to the cholinergic anti-inflammatory response.

Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM,
Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA
Clin. Transl. Immunol. 2015; 4 (12): e53. DOI: 10.1038/cti.2015.31

December 1, 2015
Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.

Biaggi-Labiosa NM, Avilés-Pagán E, Caballero-Rivera D, Báez-Pagán CA, Lasalde-Dominicci JA
Neuropharmacology. 2015; 99 (Supplement C): 273–284. DOI: 10.1016/j.neuropharm.2015.04.022

November 30, 2015
Comparison of Two Methods of Estradiol Replacement: their Physiological and Behavioral Outcomes.

Mosquera L, Shepherd L, Torrado AI, Torres-Diaz YM, Miranda JD, Segarra AC
J. Vet. Sci. Technol. 2015; 6 (6): 276. DOI: 10.4172/2157-7579.1000276

October 30, 2015
Lateral Diffusion, Function, and Expression of the Slow Channel Congenital Myasthenia Syndrome αC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components.

Oyola-Cintrón J, Caballero-Rivera D, Ballester L, Baéz-Pagán CA, Martínez HL, Vélez-Arroyo KP,
Quesada O, Lasalde-Dominicci JA
J. Biol. Chem. 2015; 290 (44): 26790–26800. DOI: 10.1074/jbc.M115.678573

PRESENTATIONS

Some of the presentations sponsored by COBRE and NIEF cores could be observed in this file:

Presentations Sponsored by COBRE