February 26, 2020
A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same)

Caballero Rivera D, Biaggi-Labiosa NM, Avilez-Pagan E, Lasalde-Dominicci JA

U.S. Patent No:  Pending

August 1, 2019

A. Valance Washington

Appl. No.: 16/242,995
Docket: UPR-14230

July 23, 2019
High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition

Lasalde-Dominicci; Jose A., Quesada-Gonzalez; Orestes, Rodriguez-Cordero, Josue, Baez-Pagan; Carlos

U. S. Patent No: 10, 358, 475

October 23, 2018
Supramolecular hacky sacks (SHS), method of synthesis and applications thereof

Rivera JM, Negrón LM

U.S. Patent No: 10,106,572

May 16, 2017
Site-directed RNA editing

Rosenthal JJC, Montiel-González MF

U.S. Patent No: 9,650,627


January 1, 2016
Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.

Padilla-Morales LF, Colón-Sáez JO, González-Nieves JE, Quesada-González O, Lasalde-Dominicci JA
Biochim. Biophys. Acta. 2016; 1858 (1): 47–56. DOI: 10.1016/j.bbamem.2015.10.002

December 11, 2015
The ∂7 nicotinic receptor is up-regulated in macrophages from HIV-seropositive women: Consequences to the cholinergic anti-inflammatory response.

Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM,
Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA
Clin. Transl. Immunol. 2015; 4 (12): e53. DOI: 10.1038/cti.2015.31

December 1, 2015
Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.

Biaggi-Labiosa NM, Avilés-Pagán E, Caballero-Rivera D, Báez-Pagán CA, Lasalde-Dominicci JA
Neuropharmacology. 2015; 99 (Supplement C): 273–284. DOI: 10.1016/j.neuropharm.2015.04.022

November 30, 2015
Comparison of Two Methods of Estradiol Replacement: their Physiological and Behavioral Outcomes.

Mosquera L, Shepherd L, Torrado AI, Torres-Diaz YM, Miranda JD, Segarra AC
J. Vet. Sci. Technol. 2015; 6 (6): 276. DOI: 10.4172/2157-7579.1000276

October 30, 2015
Lateral Diffusion, Function, and Expression of the Slow Channel Congenital Myasthenia Syndrome αC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components.

Oyola-Cintrón J, Caballero-Rivera D, Ballester L, Baéz-Pagán CA, Martínez HL, Vélez-Arroyo KP,
Quesada O, Lasalde-Dominicci JA
J. Biol. Chem. 2015; 290 (44): 26790–26800. DOI: 10.1074/jbc.M115.678573

October 1, 2015
Induction of Cancer Cell Death by Hyaluronic Acid-Mediated Uptake of Cytochrome C.

Figueroa CM, Morales-Cruz M, Suárez BN, Fernández JC, Molina AM, Quiñones CM, Griebenow K
J. Nanomedicine Nanotechnol. 2015; 6 (5): 1–9. DOI: 10.4172/2157-7439.1000316

September 1, 2015
Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons.

Palacio S, Velázquez-Marrero C, Marrero HG, Seale GE, Yudowski GA, Treistman SN
Alcohol. Clin. Exp. Res. 2015; 39 (9): 1619–1631. DOI: 10.1111/acer.12808

September 1, 2015
Ethanol Effect on BK Channels is Modulated by Magnesium.

Marrero HG, Treistman SN, Lemos JR
Alcohol. Clin. Exp. Res. 2015; 39 (9): 1671–1679. DOI: 10.1111/acer.12821

September 1, 2015
Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation.

Báez-Pagán CA, Delgado-Vélez M, Lasalde-Dominicci JA
J. Neuroimmune Pharmacol. Off. J. Soc. NeuroImmune Pharmacol. 2015; 10 (3): 468–476. DOI:

August 1, 2015
Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome.

Zhu H, Grajales-Reyes GE, Alicea-Vázquez V, Grajales-Reyes JG, Robinson K, Pytel P, Báez-Pagán
CA, Lasalde-Dominicci JA, Gomez CM
Exp. Neurol. 2015; 270 88–94. DOI: 10.1016/j.expneurol.2014.10.008

June 18, 2015
Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni.

Habib MR, Mohamed AH, Osman GY, Sharaf El-Din AT, Mossalem HS, Delgado N, Torres G,
Rolón-Martínez S, Miller MW, Croll RP,
PloS One. 2015; 10 (6): e0129800. DOI: 10.1371/journal.pone.0129800

June 10, 2015
Development of HAMLET-like Cytochrome c-Oleic Acid Nanoparticles for Cancer Therapy.

Delgado Y, Morales-Cruz M, Hernández-Román J, Hernández G, Griebenow K
J. Nanomedicine Nanotechnol. 2015; 6 (4): 1–8. DOI: 10.4172/2157-7439.1000303

June 1, 2015
Cytocompatibility of direct water synthesized cadmium selenide quantum dots in colo-205 cells.

Rodriguez-Torres MR, Velez C, Zayas B, Rivera O, Arslan Z, Gonzalez-Vega MN, Diaz-Diestra D,
Beltran-Huarac J, Morell G, Primera-Pedrozo OM
J. Nanoparticle Res. Interdiscip. Forum Nanoscale Sci. Technol. 2015; 17 (6): 1–11. DOI:

April 15, 2015
Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo.

Martin I, Cabán-Hernández K, Figueroa-Santiago O, Espino AM
J. Immunol. Baltim. Md 1950. 2015; 194 (8): 3924–3936. DOI: 10.4049/jimmunol.1401182

April 1, 2015
The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.

Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos CA, Basnakian AG, Javadov S
Am. J. Physiol. Heart Circ. Physiol. 2015; 308 (7): H749-758. DOI: 10.1152/ajpheart.00414.2014